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Literature summary extracted from

  • Abe, K.; Saito, F.; Yamada, M.; Tokui, T.
    Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid (2004), Biol. Pharm. Bull., 27, 113-116.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.19.3 0.045
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 0.046
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 0.057
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.14
-
 L-pyroglutamyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.3
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 0.33
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 0.33
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 0.37
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 0.42
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.43
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.5
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Homo sapiens
3.4.19.3 0.55
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.55
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 0.57
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 0.57
-
 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.58
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Mus musculus
3.4.19.3 0.62
-
 L-2-oxothiazolidine-4-carboxyl-ethanolamine 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 0.71
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 1.43
-
 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 1.53
-
 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Homo sapiens
-
-
-
3.4.19.3 Mus musculus
-
-
-
3.4.19.3 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Mus musculus L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Homo sapiens L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Rattus norvegicus L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-ethanolamine + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-pyroglutamyl-aminoethylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.19.3 L-pyroglutamyl-L-Ala + H2O
-
 Mus musculus L-pyroglutamate + L-Ala
-
 ?
3.4.19.3 L-pyroglutamyl-L-Ala + H2O
-
 Homo sapiens L-pyroglutamate + L-Ala
-
 ?
3.4.19.3 L-pyroglutamyl-L-Ala + H2O
-
 Rattus norvegicus L-pyroglutamate + L-Ala
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.19.3 0.9
-
 L-2-oxothiazolidine-4-carboxyl-ethanolamine 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 1.5
-
 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 1.8
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Homo sapiens
3.4.19.3 2.3
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Mus musculus
3.4.19.3 2.3
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 2.3
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 2.4
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 2.4
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 2.5
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 2.7
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 3.2
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 3.2
-
 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 3.4
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 3.5
-
 L-pyroglutamyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 3.6
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 3.7
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 6.4
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
3.4.19.3 6.6
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.4.19.3 7.6
-
 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4.19.3 8.1
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus