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Literature summary extracted from

  • Horn, M.; Doleckova-Maresova, L.; Rulisek, L.; Masa, M.; Vasiljeva, O.; Turk, B.; Gan-Erdene, T.; Baudys, M.; Mares, M.
    Activation processing of cathepsin H impairs recognition by its propeptide (2005), Biol. Chem., 386, 941-947.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.16 additional information no significant inhibitory effect of enzyme propeptide fragments, detailed analysis using several different peptides. Recombinant enzyme lacking the mini-chain shows inhibitory interaction Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Homo sapiens P09668
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.16 proteolytic modification propeptide-binding region of enzyme is structurally rearranged during maturation processing and mini-chain formation, which impairs the effective recognition of mature enzyme by its propeptide Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.16 Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens benzoyl-L-Phe-L-Val-L-Arg + 7-amino-4-methylcoumarin
-
 ?