Literature summary extracted from

Tsay, M.J.; Fatemi, N.; Narindrasorasak, S.; Forbes, J.R.; Sarkar, B.
Identification of the "missing domain" of the rat copper-transporting ATPase, atp7b: insight into the structural and metal binding characteristics of its N-terminal copper-binding domain (2004), Biochim. Biophys. Acta, 1688, 78-85.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
7.2.2.9	cloning of the DNA segment coding for the N-terminal copper-binding region into a GST pGEX-6P-2 vector	Rattus norvegicus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
7.2.2.9	Cu+	the metal-dependent conformational changes observed in the N-terminal region of the ATPase may not require the presence of the CXXC motif on every domain, as long as the domain has the proper shape, which is an heavy metal-associated-domain-like fold, and as long as some of them contain the CXXC metal binding site. At a certain point during the cooperative binding of Cu(I), protein/protein interactions among the heavy metal-associated -domains begin to dominate the conformational changes in rat ATP7B, while metal binding to the heavy metal-associated -domains makes a smaller contribution	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.2.2.9	Rattus norvegicus	Q64535	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
7.2.2.9	-	Rattus norvegicus

Synonyms

EC Number	Synonyms	Comment	Organism
7.2.2.9	ATP7B	-	Rattus norvegicus
7.2.2.9	copper-transporting ATPase	-	Rattus norvegicus

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Release 2023.1 (January 2023)