Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Baum, E.Z.; Crespo-Carbone, S.M.; Foleno, B.; Peng, S.; Hilliard, J.J.; Abbanat, D.; Goldschmidt, R.; Bush, K.
    Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A (2005), Antimicrob. Agents Chemother., 49, 4500-4507.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.13 gene ldcA, cloning from genomic DNA of strain MG1655, DNA and amino acid sequence determination and analysis Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.13 (3Z)-3-[(3-ethoxypropyl)imino]-N,N-diethyl-3H-1,2,4-dithiazol-5-amine i.e. DTZ, a dithiazoline inhibitor, specificity, overview, the compound has slight antibacterial activity against strain MG1655 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.13 additional information Escherichia coli the enzyme is involved in cell wall synthesis ?
-
 ?
3.4.17.13 additional information Escherichia coli MG1655 the enzyme is involved in cell wall synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.13 Escherichia coli
-
 gene ldcA
-
3.4.17.13 Escherichia coli MG1655
-
 gene ldcA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.13 L-Ala-gamma-D-Glu-L-Lys-D-Ala + H2O
-
 Escherichia coli ?
-
 ?
3.4.17.13 L-Ala-gamma-D-Glu-L-Lys-D-Ala + H2O
-
 Escherichia coli MG1655 ?
-
 ?
3.4.17.13 additional information the enzyme is involved in cell wall synthesis Escherichia coli ?
-
 ?
3.4.17.13 additional information the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala Escherichia coli ?
-
 ?
3.4.17.13 additional information the enzyme is involved in cell wall synthesis Escherichia coli MG1655 ?
-
 ?
3.4.17.13 additional information the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala Escherichia coli MG1655 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.13 L,D-carboxypeptidase A
-
 Escherichia coli
3.4.17.13 LdcA
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.13 37
-
 assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.13 8.5
-
 assay at Escherichia coli