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Literature summary extracted from

  • Denari, D.; Ceballos, N.R.
    Seasonal changes in the activity of 11 beta-hydroxysteroid dehydrogenase in toad testes (2005), Ann. N. Y. Acad. Sci., 1040, 297-300.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 glycyrrhetinic acid strong inhibition of isozyme 11beta-HSD2 Rhinella arenarum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.00013
-
 corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, R period Rhinella arenarum
1.1.1.B40 0.00014
-
 corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, PR period Rhinella arenarum
1.1.1.B40 0.00028
-
 corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, P period Rhinella arenarum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.B40 microsome isozyme 11beta-HSD2 Rhinella arenarum
-
-
1.1.1.B40 mitochondrion isozyme 11beta-HSD2 Rhinella arenarum 5739
-
1.1.1.B40 additional information subcellular localization of isozyme 11beta-HSD2, overview, isozyme 11beta-HSD2 activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, overview Rhinella arenarum
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ Rhinella arenarum isozyme 11beta-HSD2 11-dehydrocorticosterone + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Rhinella arenarum
-
 isozyme 11beta-HSD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 additional information isozyme 11beta-HSD2activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, activity is highest in P period, overview Rhinella arenarum
-
1.1.1.B40 testis isozyme 11beta-HSD2 Rhinella arenarum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.B40 additional information
-
 isozyme 11beta-HSD2 activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, activity is highest in P period, overview Rhinella arenarum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ isozyme 11beta-HSD2 Rhinella arenarum 11-dehydrocorticosterone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11 beta-hydroxysteroid dehydrogenase
-
 Rhinella arenarum
1.1.1.B40 11beta-HSD2
-
 Rhinella arenarum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 28
-
 assay at Rhinella arenarum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.B40 8
-
 assay at Rhinella arenarum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+ isozyme 11beta-HSD2, dependent on Rhinella arenarum