Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shin, Y.; Vaziri, N.D.; Willekes, N.; Kim, C.H.; Joles, J.A.
    Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia (2005), Am. J. Physiol. Endocrinol. Metab., 289, E993-E998.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus rate-limiting enzyme in cholesterol conversion to bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus Sprague-Dawley rate-limiting enzyme in cholesterol conversion to bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 additional information Rattus norvegicus the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism ?
-
 ?
1.14.14.23 additional information Rattus norvegicus Sprague-Dawley the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
 Sprague-Dawley
-
1.1.1.34 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
1.14.14.23 Rattus norvegicus
-
 Sprague-Dawley and Nagase analbuminemic rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver HMG-CoA reductase activity is higher in both female and male Nagase analbumimetic rats than in Sprague-Dwwley rats. Ovariectomy results in no significant changes in total hepatic HMG-CoA reductase in female Sprague-Dawley rats Rattus norvegicus
-
1.14.14.23 liver effects of gender on hepatic enzyme activity, overview Rattus norvegicus
-
1.14.14.23 additional information enzyme activity in rats of different strains and with different sexes, the enzyme is upregulated in both female and male Nagase analbuminemic rats compared to Sprague-Dawley rats, overview Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.23 additional information
-
 enzyme activity in rats of different strains and with different sexes, overview Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 rate-limiting enzyme in cholesterol conversion to bile acids Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus Sprague-Dawley 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 rate-limiting enzyme in cholesterol conversion to bile acids Rattus norvegicus Sprague-Dawley 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 additional information the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism Rattus norvegicus ?
-
 ?
1.14.14.23 additional information the sex difference in plasma cholesterol content diminishes after ovariectomy, hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats, molecular mechanism Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
 Rattus norvegicus
1.14.14.23 cholesterol 7alpha-hydroxylase
-
 Rattus norvegicus
1.14.14.23 CYP7A1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 NADPH
-
 Rattus norvegicus