Literature summary extracted from

Dantas, A.P.; Sandberg, K.
Regulation of ACE2 and ANG-(1-7) in the aorta: New insights into the renin-angiotensin system in the control of vascular function (2005), Am. J. Physiol., 289, H980-H981.

Application

EC Number	Application	Comment	Organism
3.4.17.23	medicine	chronic treatment with the AT1R antagonist almesartan induces a fivefold increase in ACE2 mRNA in the aorta which leads to a significant increase in aortic angiotensin(1-7) protein expression. These effects are associated with significant decreases in aortic medial thickness and may represent an important protective mechanism in the prevention of cardiovascular events in hypertensive subjects	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.17.23	Rattus norvegicus	-	spontaneously hypertensive rat	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.17.23	aorta thoracica	chronic treatment with the AT1R antagonist almesartan induces a fivefold increase in ACE2 mRNA in the aorta which leads to a significant increase in aortic angiotensin(1-7) protein expression	Rattus norvegicus	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.17.23	ACE	-	Rattus norvegicus

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Release 2023.1 (January 2023)