Literature summary extracted from

Nassogne, M.C.; Lizarraga, C.; N'Kuli, F.; Van Bambeke, F.; Van Binst, R.; Wallemacq, P.; Tulkens, P.M.; Mingeot-Leclercq, M.P.; Levade, T.; Courtoy, P.J.
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1 (2004), Toxicol. Appl. Pharmacol., 194, 101-110.

Application

EC Number	Application	Comment	Organism
3.1.1.32	medicine	acidotropic accumulation of cocaine in lysosomes inhibits acid phospholipase A1 and inactivates acid sphingomyelinase, inducing a mixed lysosomal lipidosis	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.32	cocaine	10 mM, below 10% residual activity	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.1.32	lysosome	-	Rattus norvegicus	5764	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.32	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.32	cell culture	fibroblast	Rattus norvegicus	-
3.1.1.32	fibroblast	cultured cells	Rattus norvegicus	-

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Release 2023.1 (January 2023)