EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | alpha-interferon | induces IDO expression in monocytes | Homo sapiens | |
1.13.11.52 | beta-interferon | induces IDO expression in monocytes | Homo sapiens | |
1.13.11.52 | gamma-interferon | induces IDO expression | Mus musculus | |
1.13.11.52 | gamma-interferon | induces IDO expression | Homo sapiens | |
1.13.11.52 | gamma-interferon | induces IDO expression | Oryctolagus cuniculus | |
1.13.11.52 | hyperoxia | induces IDO expression in the lung | Oryctolagus cuniculus | |
1.13.11.52 | lipopolysaccharide | induces IDO expression in monocytes | Homo sapiens | |
1.13.11.52 | lipopolysaccharide | induces IDO expression in the lung | Oryctolagus cuniculus | |
1.13.11.52 | paraquat | induces IDO expression in the lung | Oryctolagus cuniculus |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.13.11.52 | medicine | plays a role in the antiparasitic defense in humans, inhibits the growth of tumor cell lines in vitro, inhibits T lymphocyte proliferation | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | 1-Methyltryptophan | treatment of pregnant mice result in rapid T-cell-induces rejection of allogeneic concepti | Mus musculus | |
1.13.11.52 | dexamethasone | inhibits IDO activity in brain and lung after systemic pokeweed mitogen administration and brains of mice suffering from malaria | Mus musculus | |
1.13.11.52 | dexamethasone | - |
Oryctolagus cuniculus | |
1.13.11.52 | H2O2 | - |
Homo sapiens | |
1.13.11.52 | H2O2 | - |
Mus musculus | |
1.13.11.52 | interleukin-4 | - |
Homo sapiens | |
1.13.11.52 | NO | - |
Homo sapiens | |
1.13.11.52 | NO | inhibits the transcription of IDO in murine macrophages | Mus musculus | |
1.13.11.52 | transforming growth factor-beta | inhibits expression in skin and synovial fibroblasts | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-L-kynurenine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.52 | Homo sapiens | - |
- |
- |
1.13.11.52 | Mus musculus | - |
pregnant | - |
1.13.11.52 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.52 | brain | - |
Homo sapiens | - |
1.13.11.52 | cerebrospinal fluid | from humans suffering from inflammatory neurological disorders exhibit increased IDO activity | Homo sapiens | - |
1.13.11.52 | epididymis | - |
Mus musculus | - |
1.13.11.52 | lung | - |
Mus musculus | - |
1.13.11.52 | lung | - |
Oryctolagus cuniculus | - |
1.13.11.52 | lung | cancer bearing lung exhibits 20fold increase in IDO activity | Homo sapiens | - |
1.13.11.52 | monocyte | induced by alpha-, beta- and gamma-interferon | Homo sapiens | - |
1.13.11.52 | skin fibroblast | - |
Homo sapiens | - |
1.13.11.52 | small intestine | - |
Mus musculus | - |
1.13.11.52 | synovial fibroblast | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.52 | IDO | - |
Mus musculus |
1.13.11.52 | IDO | - |
Homo sapiens |
1.13.11.52 | IDO | - |
Oryctolagus cuniculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | additional information | O2- | Mus musculus | |
1.13.11.52 | additional information | O2- | Homo sapiens | |
1.13.11.52 | additional information | O2- | Oryctolagus cuniculus |