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Literature summary extracted from

  • Roy, E.J.; Takikawa, O.; Kranz, D.M.; Brown, A.R.; Thomas, D.L.
    Neuronal localization of indoleamine 2,3-dioxygenase in mice (2005), Neurosci. Lett., 387, 95-99.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 gamma-interferon induces IDO expression Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Mus musculus
-
 N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Mus musculus
-
-
-
1.13.11.52 Mus musculus
-
 C57BL6J and murine cell lines P815B murine mastocytoma cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 brain
-
 Mus musculus
-
1.13.11.52 hippocampus neurons, level of activity is lower than in monocytic cells in lymph nodes Mus musculus
-
1.13.11.52 hippocampus the enzyme is upregulated by interferon-gamma in neurons of the hippocampus Mus musculus
-
1.13.11.52 macrophage
-
 Mus musculus
-
1.13.11.52 microglia
-
 Mus musculus
-
1.13.11.52 additional information entorhinal cortex Mus musculus
-
1.13.11.52 neuron the enzyme is upregulated by interferon-gamma in neurons of the hippocampus. The enzyme could contribute to the vulnerability of neurons to inflammatory conditions Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Mus musculus N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Mus musculus