BRENDA - Enzyme Database

Iazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction

Garcia-Murillas, I.; Pettitt, T.; Macdonald, E.; Okkenhaug, H.; Georgiev, P.; Trivedi, D.; Hassan, B.; Wakelam, M.; Raghu, P.; Neuron 49, 533-546 (2006)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
construction of loss-of-function enzyme mutants by transposon mutagenesis, wild-type enzyme overexpression enhances retinal degeneration of the diacylglycerol kinase causing the rdgA phenotype, overview
Drosophila melanogaster
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
endoplasmic reticulum
-
Drosophila melanogaster
5783
-
3.1.3.4
membrane
-
Drosophila melanogaster
16020
-
3.1.3.4
photoreceptor outer segment membrane
-
Drosophila melanogaster
42622
-
3.1.3.4
plasma membrane
-
Drosophila melanogaster
5886
-
3.1.3.4
rhabdomere
-
Drosophila melanogaster
16028
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Drosophila melanogaster
the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview
?
-
-
-
3.1.3.4
phosphatidic acid + H2O
Drosophila melanogaster
-
1,2-diacyl-sn-glycerol + phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Drosophila melanogaster
-
gene Iaza or Iazaro
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
retina
-
Drosophila melanogaster
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.3.4
additional information
-
-
Drosophila melanogaster
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview
666452
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
666452
Drosophila melanogaster
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
construction of loss-of-function enzyme mutants by transposon mutagenesis, wild-type enzyme overexpression enhances retinal degeneration of the diacylglycerol kinase causing the rdgA phenotype, overview
Drosophila melanogaster
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
endoplasmic reticulum
-
Drosophila melanogaster
5783
-
3.1.3.4
membrane
-
Drosophila melanogaster
16020
-
3.1.3.4
photoreceptor outer segment membrane
-
Drosophila melanogaster
42622
-
3.1.3.4
plasma membrane
-
Drosophila melanogaster
5886
-
3.1.3.4
rhabdomere
-
Drosophila melanogaster
16028
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Drosophila melanogaster
the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview
?
-
-
-
3.1.3.4
phosphatidic acid + H2O
Drosophila melanogaster
-
1,2-diacyl-sn-glycerol + phosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
retina
-
Drosophila melanogaster
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.1.3.4
additional information
-
-
Drosophila melanogaster
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
additional information
the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview
666452
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
666452
Drosophila melanogaster
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?