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Literature summary extracted from
- The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function (2006), Mol. Microbiol., 61, 526-543.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.13 | additional information | disruption of the region between the signal peptidase cleavage site and the LPNTG sorting motif results in a localization defect, premature degradation, and an alteration of the ability of the enzyme to act on a monoclonal human IgA1 substrate | Streptococcus pneumoniae |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.72 | cell surface | - |
Streptococcus pneumoniae | 9986 | - |
| 3.4.24.13 | membrane | associated to external side of bacterial membrane. Localization requires the LPNTG sorting motif near the amino terminus of protein | Streptococcus pneumoniae | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.72 | IgA1 + H2O | Streptococcus pneumoniae | - |
? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.72 | Streptococcus pneumoniae | - |
- |
- |
| 3.4.24.13 | Streptococcus pneumoniae | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.13 | proteolytic modification | correct localization requires the LPNTG sorting motif near the amino terminus of protein. Processing takes place at a site downstream of the sorting signal. Non-covalent re-association between the carboxyterminal enzymatic domain and the cleaved, sorted aminoterminal domain | Streptococcus pneumoniae |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.72 | - |
Streptococcus pneumoniae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.72 | IgA1 + H2O | - |
Streptococcus pneumoniae | ? | - |
? | |
| 3.4.21.72 | IgA1 + H2O | 37°C | Streptococcus pneumoniae | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.72 | Iga | - |
Streptococcus pneumoniae |
| 3.4.21.72 | IgA protease | - |
Streptococcus pneumoniae |
| 3.4.21.72 | IgA1-specific protease | - |
Streptococcus pneumoniae |
| 3.4.24.13 | Iga | - |
Streptococcus pneumoniae |
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Release 2023.1 (January 2023)
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