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Literature summary extracted from

  • Bentley, G.N.; Jones, A.K.; Agnew, A.
    Expression and comparative functional characterization of recombinant acetylcholinesterase from three species of Schistosoma (2005), Mol. Biochem. Parasitol., 141, 119-123.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 BW284c51 50% inhibition at 0.0025 mM Schistosoma bovis
3.1.1.7 BW284c51 50% inhibition at 0.002 mM Schistosoma haematobium
3.1.1.7 BW284c51 50% inhibition at 0.0022 mM Schistosoma mansoni
3.1.1.7 dichlorvos 50% inhibition at 0.00059 mM Schistosoma bovis
3.1.1.7 dichlorvos 50% inhibition at 0.00058 mM Schistosoma haematobium
3.1.1.7 dichlorvos 50% inhibition at 0.00056 mM Schistosoma mansoni
3.1.1.7 eserine 50% inhibition at 0.00054 mM Schistosoma bovis
3.1.1.7 eserine 50% inhibition at 0.0006 mM Schistosoma haematobium
3.1.1.7 eserine 50% inhibition at 0.0005 mM Schistosoma mansoni
3.1.1.7 propidium 50% inhibition at 0.196 mM Schistosoma bovis
3.1.1.7 propidium 50% inhibition at 0.114 mM Schistosoma haematobium
3.1.1.7 propidium 50% inhibition at 0.155 mM Schistosoma mansoni

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.189
-
 acetylthiocholine
-
 Schistosoma bovis
3.1.1.7 0.196
-
 acetylthiocholine
-
 Schistosoma mansoni
3.1.1.7 0.199
-
 acetylthiocholine
-
 Schistosoma haematobium
3.1.1.7 0.374
-
 butyrylthiocholine
-
 Schistosoma mansoni
3.1.1.7 0.395
-
 butyrylthiocholine
-
 Schistosoma bovis
3.1.1.7 0.399
-
 butyrylthiocholine
-
 Schistosoma haematobium

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Schistosoma bovis Q71SU5
-
-
3.1.1.7 Schistosoma haematobium Q86GL8
-
-
3.1.1.7 Schistosoma mansoni Q71SU7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Schistosoma mansoni thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Schistosoma haematobium thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Schistosoma bovis thiocholine + acetate
-
 ?
3.1.1.7 butyrylthiocholine + H2O
-
 Schistosoma mansoni butyrate + thiocholine
-
 ?
3.1.1.7 butyrylthiocholine + H2O
-
 Schistosoma haematobium butyrate + thiocholine
-
 ?
3.1.1.7 butyrylthiocholine + H2O
-
 Schistosoma bovis butyrate + thiocholine
-
 ?