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Literature summary extracted from

  • Rose, A.J.; Broholm, C.; Kiillerich, K.; Finn, S.G.; Proud, C.G.; Rider, M.H.; Richter, E.A.; Kiens, B.
    Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men (2005), J. Physiol., 569, 223-228.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 Calmodulin strong activation, activation in response to exercise in skeletal muscle Homo sapiens
2.7.11.20 additional information 90 min continuous exercise rapidly increases eukaryotic elongation factor 2 phosphorylation 5-7fold within 1 minute in skeletal muscle of male humans, activation does not function by covalent mechanisms but by allosteric mechanisms involving Ca2+ signaling via calmodulin Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ strong activation, activation in response to exercise in skeletal muscle Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] Homo sapiens phosphorylation at Thr56 ADP + [elongation factor 2]phosphate
-
 ?
2.7.11.20 additional information Homo sapiens the enzyme regulates protein synthesis in skeletal muscle ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Homo sapiens
-
 male humans of about 25 years
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] phosphorylation at Thr56 Homo sapiens ADP + [elongation factor 2]phosphate
-
 ?
2.7.11.20 additional information the enzyme regulates protein synthesis in skeletal muscle Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2 kinase
-
 Homo sapiens
2.7.11.20 eukaryotic elongation factor 2 kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.20 ATP
-
 Homo sapiens