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Literature summary extracted from

  • Kunii, R.; Nemoto, E.; Kanaya, S.; Tsubahara, T.; Shimauchi, H.
    Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13 (2005), J. Periodontal Res., 40, 138-146.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.2 additional information up-regulation of enzyme expression upon stimulation with interleukin-4 and interleukin-13 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 1,10-phenanthroline 92.5% inhibition at 1 mM Homo sapiens
3.4.11.2 bestatin 83.7% inhibition at 1 mM Homo sapiens
3.4.11.2 EDTA 35.5% inhibition at 5 mM Homo sapiens
3.4.11.2 additional information no inhibition by pepstatin, phosphoramidon, and aprotinin Homo sapiens
3.4.11.2 PMSF 4.5% inhibition at 1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 cell surface ectoenzyme Homo sapiens 9986
-
3.4.11.2 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.2 additional information Homo sapiens the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 fibroblast gingival Homo sapiens
-
3.4.11.2 gingiva
-
 Homo sapiens
-
3.4.11.2 leukocyte polymorphonuclear leukocytes, i.e. PMN, from heparinized venous blood Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 Glu-Ala-Ala-4-methoxynaphthylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.2 L-Leu-4-nitroanilide + H2O
-
 Homo sapiens L-Leu + 4-nitroaniline
-
 ?
3.4.11.2 additional information the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Homo sapiens
3.4.11.2 CD13
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.11.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.2 6.5 7.6 assay at, dependent on substrate used Homo sapiens