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Literature summary extracted from

  • Loh, H.H.; Berg, C.P.
    D-Tryptophan pyrrolase activity in the liver and the intestine of the rat (1972), J. Nutr., 102, 1331-1339.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 cortisone subcutaneously Rattus norvegicus
1.13.11.52 D-tryptophan 2g subcutaneously Rattus norvegicus
1.13.11.52 hematine
-
 Rattus norvegicus
1.13.11.52 L-tryptophan 2g subcutaneously Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Rattus norvegicus
-
 N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Rattus norvegicus
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52 dialysis, lyophilization Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 intestine intestinal mucosa of rat exhibits lower activity than in rabbit Rattus norvegicus
-
1.13.11.52 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.52 0.000192
-
 L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment Rattus norvegicus
1.13.11.52 0.000208
-
 D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment Rattus norvegicus
1.13.11.52 0.000224
-
 D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with neomycin Rattus norvegicus
1.13.11.52 0.000245
-
 L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone Rattus norvegicus
1.13.11.52 0.000256
-
 D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone Rattus norvegicus
1.13.11.52 0.000272
-
 L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan Rattus norvegicus
1.13.11.52 0.000277
-
 D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Rattus norvegicus N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Rattus norvegicus N-formyl-L-kynurenine
-
 ?