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Literature summary extracted from

  • Samuvel, D.J.; Jayanthi, L.D.; Bhat, N.R.; Ramamoorthy, S.
    A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression (2005), J. Neurosci., 25, 29-41.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 beta-phorbol-13-acetate stimulates SERT phosphorylation Rattus norvegicus
2.7.11.24 D-amphetamine stimulates SERT phosphorylation Rattus norvegicus
2.7.11.24 additional information p38 MAPK needs to be activated by phosphorylation Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.24 expression of p38 MAPK in HEK293 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 PD169316 i.e. 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation Rattus norvegicus
2.7.11.24 SB203580 i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 synaptosome from midbrain Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 additional information Rattus norvegicus p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein p38 MAPK needs to be activated by phosphorylation Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.24 purification of synaptosomes Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 additional information p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 p38 MAPK
-
 Rattus norvegicus
2.7.11.24 p38 mitogen-activated protein kinase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.24 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.24 7.5
-
 assay at Rattus norvegicus