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Literature summary extracted from

  • Walter, L.; Dinh, T.; Stella, N.
    ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase (2004), J. Neurosci., 24, 8068-8074.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.23 EDTA slightly activating Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 arachidonyl trifluoromethylketone
-
 Mus musculus
3.1.1.23 ATP slightly inhibiting Mus musculus
3.1.1.23 methyl arachidonyl fluorophosphonate
-
 Mus musculus
3.1.1.23 additional information no inhibition by PMSF and palmityl trifluoromethyl ketone Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.23 cytoplasm
-
 Mus musculus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.23 Ca2+ slightly activating Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.23 30000
-
 x * 30000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O Mus musculus 2-arachidonoylglycerol is an endocannabinoid which prevents the propagation of harmful neuroinflammation and may function as a gliotransmitter arachidonic acid + glycerol
-
 ?
3.1.1.23 additional information Mus musculus inhibition of the enzyme potentiates the activation of 2-arachidonoylglycerol production by ATP ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 astrocyte primary Mus musculus
-
3.1.1.23 cell culture
-
 Mus musculus
-
3.1.1.23 neuron primary Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Mus musculus arachidonic acid + glycerol
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O 2-arachidonoylglycerol is an endocannabinoid which prevents the propagation of harmful neuroinflammation and may function as a gliotransmitter Mus musculus arachidonic acid + glycerol
-
 ?
3.1.1.23 additional information inhibition of the enzyme potentiates the activation of 2-arachidonoylglycerol production by ATP Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.23 ? x * 30000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MGL
-
 Mus musculus
3.1.1.23 monoacylglycerol lipase
-
 Mus musculus