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Literature summary extracted from

  • Yamamoto, H.; Hiragami, Y.; Murayama, M.; Ishizuka, K.; Kawahara, M.; Takashima, A.
    Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain (2005), J. Neurochem., 94, 1438-1447.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Homo sapiens
2.7.11.17 Calmodulin dependent on Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expressed in GT1-7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93
-
 Homo sapiens
2.7.11.17 KN-93
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cell soma brain Rattus norvegicus
-
-
2.7.11.17 cell soma neuron Homo sapiens
-
-
2.7.11.17 additional information distribution in hippocampal neurons: CaM kinase II is located in neurites and neuronal soma Homo sapiens
-
-
2.7.11.17 neurite
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Homo sapiens
2.7.11.17 Ca2+ dependent on Rattus norvegicus
2.7.11.17 Mg2+
-
 Homo sapiens
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + tau protein Rattus norvegicus phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development ADP + phosphorylated tau protein
-
 ?
2.7.11.17 ATP + tau protein Homo sapiens phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain ADP + phosphorylated tau protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
 isozyme CaM kinase IIalpha
-
2.7.11.17 Rattus norvegicus
-
 isozyme CaM kinase IIalpha
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain cortex, soma, Alzheimer's disease brain Homo sapiens
-
2.7.11.17 brain soma Rattus norvegicus
-
2.7.11.17 hippocampus primary hippocampal neurons Homo sapiens
-
2.7.11.17 hippocampus primary hippocampal neurons Rattus norvegicus
-
2.7.11.17 neuron primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells Homo sapiens
-
2.7.11.17 neuron primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + tau peptide 408-420 recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Homo sapiens ADP + phosphorylated tau peptide 408-420
-
 ?
2.7.11.17 ATP + tau peptide 408-420 recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Rattus norvegicus ADP + phosphorylated tau peptide 408-420
-
 ?
2.7.11.17 ATP + tau protein phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development Rattus norvegicus ADP + phosphorylated tau protein
-
 ?
2.7.11.17 ATP + tau protein phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain Homo sapiens ADP + phosphorylated tau protein
-
 ?
2.7.11.17 ATP + tau protein recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Homo sapiens ADP + phosphorylated tau protein
-
 ?
2.7.11.17 ATP + tau protein recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Rattus norvegicus ADP + phosphorylated tau protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaM kinase II
-
 Homo sapiens
2.7.11.17 CaM kinase II
-
 Rattus norvegicus
2.7.11.17 CaM kinase IIalpha
-
 Homo sapiens
2.7.11.17 CaM kinase IIalpha
-
 Rattus norvegicus
2.7.11.17 More cf. EC 2.7.11.26 Homo sapiens
2.7.11.17 More cf. EC 2.7.11.26 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Homo sapiens
2.7.11.17 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.5
-
 assay at Homo sapiens
2.7.11.17 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens
2.7.11.17 ATP
-
 Rattus norvegicus