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Literature summary extracted from

  • Nishimura, H.; Sakagami, H.; Uezu, A.; Fukunaga, K.; Watanabe, M.; Kondo, H.
    Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase Ig in the rat brain (2003), J. Neurochem., 85, 1216-1227.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on, activates Rattus norvegicus
2.7.11.17 additional information CaMKIgamma1 is activated by the calmodulin-dependent protein kinase kinase, CaMKK, while CaMKIgamma2 is not Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 CaMKIgamma1 and CaMKIgamma2, DNA and amino acid sequence, and genomic structure determination and analysis, expression of FLAG-tagged enzymes in COS_7 cells, hippocampal neurons, and NG108-15 cells in the cytoplasm and neurites, not in the nucleus Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytoplasm
-
 Rattus norvegicus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, activates Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.17 43000
-
 x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE Rattus norvegicus
2.7.11.17 53000
-
 x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Rattus norvegicus CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus Q7TNJ7 isozyme CaMKIgamma; two alternative splicing isoforms of CaMKIgamma
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein CaMKIgamma1 is activated by the calmodulin-dependent protein kinase kinase, CaMKK, while CaMKIgamma2 is not Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain two alternative splicing isoforms of CaMKIgamma, expression patterns in brain regions, such as the olfactory bulb, hippocampal pyramidal cell layer of CA3, central amygdaloid nuclei, ventromedial hypothalamic nucleus, and pineal gland, overview Rattus norvegicus
-
2.7.11.17 central amygdaloid nucleus
-
 Rattus norvegicus
-
2.7.11.17 hippocampal pyramidal layer
-
 Rattus norvegicus
-
2.7.11.17 hypothalamus
-
 Rattus norvegicus
-
2.7.11.17 neuron
-
 Rattus norvegicus
-
2.7.11.17 olfactory bulb
-
 Rattus norvegicus
-
2.7.11.17 pineal gland
-
 Rattus norvegicus
-
2.7.11.17 ventromedial hypothalamic nucleus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + YLRRRLSDSNF synapsin site I-derived peptide substrate Rattus norvegicus ADP + ?
-
 ?
2.7.11.17 additional information CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 ? x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase Igamma
-
 Rattus norvegicus
2.7.11.17 Ca2+/calmodulin-dependent protein kinase type IG
-
 Rattus norvegicus
2.7.11.17 CamkG
-
 Rattus norvegicus
2.7.11.17 CaMKI
-
 Rattus norvegicus
2.7.11.17 CaMKIgamma
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.17 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.17 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus