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Literature summary extracted from

  • Robinson, D.A.; Stewart, K.A.; Price, N.C.; Chalk, P.A.; Coggins, J.R.; Lapthorn, A.J.
    Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New Directions for Inhibitor Design (2006), J. Med. Chem., 49, 1282-1290.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.10 sitting drop vapor diffusion method, crystal structures of type II dehydroquinase with the inhibitors 2,3-anhydroquinate, citrate or N-tetrazol-5-yl-9-oxo-9H-xanthene-2-sulfonamide Helicobacter pylori

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 2,3-anhydroquinate
-
 Helicobacter pylori
4.2.1.10 citrate
-
 Helicobacter pylori
4.2.1.10 N-tetrazol-5-yl-9-oxo-9H-xanthene-2-sulfonamide
-
 Helicobacter pylori

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Helicobacter pylori Q48255
-
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 Type II dehydroquinase
-
 Helicobacter pylori

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.10 0.0025
-
 citrate
-
 Helicobacter pylori
4.2.1.10 0.02
-
 N-tetrazol-5-yl-9-oxo-9H-xanthene-2-sulfonamide
-
 Helicobacter pylori
4.2.1.10 0.37
-
 2,3-anhydroquinate
-
 Helicobacter pylori