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Literature summary extracted from
- Isolation and characterization of a microsomal acid retinyl ester hydrolase (2005), J. Biol. Chem., 280, 23287-23294.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.1 | Triton X-100 | 3fold stimulation | Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.1 | 0.086 | - |
retinyl palmitate | pH 5.0, 37°C | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.1 | microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 62000 | - |
3 * 62000, mass spectrometry, deglycosylated enzyme, 3* 60300, mass spectrometry | Rattus norvegicus |
| 3.1.1.1 | 176000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.1 | Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.1.1 | glycoprotein | N-linked glycosylation, high mannose-type carbohydrate | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.1 | heart | - |
Rattus norvegicus | - |
| 3.1.1.1 | kidney | - |
Rattus norvegicus | - |
| 3.1.1.1 | liver | high expression | Rattus norvegicus | - |
| 3.1.1.1 | lung | high expression | Rattus norvegicus | - |
| 3.1.1.1 | testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 437 | - |
pH 5.0, 37°C | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.1 | additional information | no substrate: cholesteryl oleate | Rattus norvegicus | ? | - |
? | |
| 3.1.1.1 | retinyl palmitate + H2O | - |
Rattus norvegicus | retinol + palmitate | - |
? | |
| 3.1.1.1 | triolein + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.1 | trimer | 3 * 62000, mass spectrometry, deglycosylated enzyme, 3* 60300, mass spectrometry | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.1 | acid retinyl ester hydrolase | - |
Rattus norvegicus |
| 3.1.1.1 | AREH | - |
Rattus norvegicus |
| 3.1.1.1 | ES-10 | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 8 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 5 | 7.4 | 80-90% of maximum activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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