Literature summary extracted from

Hirche, T.O.; Crouch, E.C.; Espinola, M.; Brokelman, T.J.; Mecham, R.P.; DeSilva, N.; Cooley, J.; Remold-O'Donnell, E.; Belaaouaj, A.
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain (2004), J. Biol. Chem., 279, 27688-27698.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.76	4-(2-aminoethyl)benzenesulfonyl fluoride	-	Homo sapiens
3.4.21.76	diisopropyl fluorophosphate	-	Homo sapiens
3.4.21.76	phenylmethylsulfonyl fluoride	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.76	Homo sapiens	P24158	-	-
3.4.21.76	Mus musculus	Q61096	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.76	lung	-	Homo sapiens	-
3.4.21.76	lung	-	Mus musculus	-
3.4.21.76	neutrophil	-	Homo sapiens	-
3.4.21.76	neutrophil	-	Mus musculus	-
3.4.21.76	sputum	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.76	N-Boc-Ala-o-nitrophenol + H2O	37°C, pH 7.4	Homo sapiens	?	-	?
3.4.21.76	surfactant protein D + H2O	-	Mus musculus	?	a fragment of about 35000 Da	?
3.4.21.76	surfactant protein D + H2O	37°C, pH 7.4	Homo sapiens	?	a fragment of about 35000 Da	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.76	Proteinase-3	-	Homo sapiens
3.4.21.76	Proteinase-3	-	Mus musculus

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Release 2023.1 (January 2023)