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Literature summary extracted from

  • James, E.S.; Cronan, J.E.
    Expression of two Escherichia coli acetyl-CoA carboxylase subunits is autoregulated (2004), J. Biol. Chem., 279, 2520-2527.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 biotin required for subunit AccB activity, biotin is not involved in regulation of operon accBC transcription Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.4.1.2 genes accA, accB, accC, and accD, operon accBC shows nonlinear response to the gene copy number so that 50 or more copies result in an only 2-3fold increase in subunits AccB and AccC, AccB is a negative regulator for transcription of the accBC operon Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
6.4.1.2 additional information a constructed truncation mutant of subunit AccB comprising the 68 N-terminal residues is sufficient for negative regulation of accBC operon transcription, an accA and accB null mutant strain expressing the accB gene of Rhizobium trifolii is not reduced in growth under conditions that result in highly reduced growth for the wild-type strain Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 additional information subunit AccB is a negative autoregulator of the accBC operon, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Escherichia coli first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB ADP + malonyl-CoA + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Escherichia coli
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.4.1.2 additional information the enzyme is biotinylated at the biotinyl domain of subunit AccB by the biotin-[acetyl-CoA carboxylase] ligase BirA, EC 6.3.4.15 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 tetramer the four subunits are encoded by genes accA, accB, accC, and accD Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACC
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
 Escherichia coli