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Literature summary extracted from

  • Ranaei-Siadat, S.O.; Riazi, G.H.; Sadeghi, M.; Chang, L.S.; Lin, S.R.; Eghtesadi-Araghi, P.; Hakimelahi, G.H.; Moosavi-Movahedi, A.A.
    Modification of substrate inhibition of synaptosomal acetylcholinesterase by cardiotoxins (2004), J. Biochem. Mol. Biol., 37, 330-338.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.7 cardiotoxin I activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
3.1.1.7 cardiotoxin II activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
3.1.1.7 cardiotoxin III activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
3.1.1.7 cardiotoxin n activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
3.1.1.7 cardiotoxin V activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
3.1.1.7 additional information in presence of cardiotoxin IV, substrate inhibition persists Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 acetylthiocholine
-
 Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.082
-
 acetylthiocholine pH 7.4 Ovis aries
3.1.1.7 0.106
-
 acetylthiocholine pH 7.4, presence of cardiotoxin V Ovis aries
3.1.1.7 0.124
-
 acetylthiocholine pH 7.4, presence of cardiotoxin I Ovis aries
3.1.1.7 0.139
-
 acetylthiocholine pH 7.4, presence of cardiotoxin n Ovis aries
3.1.1.7 0.14
-
 acetylthiocholine pH 7.4, presence of cardiotoxin II Ovis aries
3.1.1.7 0.144
-
 acetylthiocholine pH 7.4, presence of cardiotoxin III Ovis aries
3.1.1.7 0.181
-
 acetylthiocholine pH 7.4, presence of cardiotoxin IV Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 brain cortex Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Ovis aries thiocholine + acetate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 0.84
-
 acetylthiocholine pH 7.4 Ovis aries