Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, Y.; Florova, G.; Reynolds, K.A.
    Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH) (2005), J. Bacteriol., 187, 3795-3799.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.180 additional information mutagenic replacement of the chromosomal endogenous enzyme by a plasmid-encoded Escherichia coli enzyme leads to a highly altered fatty acid profile in Streptomyces coelicolor, while plasmid-encoded expression of the Streptomyces glaucescens enzyme alters the fatty acid profile only slightly, overview Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Streptomyces coelicolor the enzyme initiates the fatty acid biosynthesis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 additional information Streptomyces coelicolor fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Streptomyces coelicolor acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme initiates the fatty acid biosynthesis Streptomyces coelicolor acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 additional information substrate specificity Streptomyces coelicolor ?
-
 ?
2.3.1.180 additional information fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview Streptomyces coelicolor ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 3-ketoacyl acyl carrier protein synthase III
-
 Streptomyces coelicolor
2.3.1.180 FabH
-
 Streptomyces coelicolor