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Literature summary extracted from

  • Yamaguchi, N.
    Neurosin or human kallikrein 6 (2004), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, 2, 1585-1587.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B10 antipain
-
 Homo sapiens
3.4.21.B10 Aprotinin
-
 Homo sapiens
3.4.21.B10 leupeptin
-
 Homo sapiens
3.4.21.B10 PMSF
-
 Homo sapiens
3.4.21.B10 Soybean trypsin inhibitor
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.B10 0.3
-
 benzoyl-L-Arg-7-amido-4-methylcoumarin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B10 Homo sapiens
-
-
-
3.4.21.B10 Mus musculus
-
-
-
3.4.21.B10 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.B10 glycoprotein
-
 Homo sapiens
3.4.21.B10 proteolytic modification the enzyme is produced as a preproform. After cleavage of 16 amino acid signal peptide, the proenzyme has a single protease domain with an N-glycosylation site. the proenzyme peptide has the sequence EEQNK Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B10 amyloid plaque
-
 Homo sapiens
-
3.4.21.B10 brain predominantly expressed in brain. Located not only in the activated microglia cells but also in amyloid plaque and neurofilament tangles in Alzheimer fluid Homo sapiens
-
3.4.21.B10 cerebrospinal fluid present as the proenzyme Homo sapiens
-
3.4.21.B10 Colo-201 cell
-
 Homo sapiens
-
3.4.21.B10 microglia
-
 Homo sapiens
-
3.4.21.B10 neurofibrillary tangle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B10 benzoyl-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzoyl-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B10 N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B10 N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B10 N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?