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Literature summary extracted from

  • Diaz, V.M.; Hurtado, M.; Thomson, T.M.; Reventos, J.; Paciucci, R.
    Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro (2004), Gut, 53, 993-1000.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 plasminogen activator inhibitor 1 physiological inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.68 additional information colocalised with annexin II Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.68 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Homo sapiens P00750
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 PANC-1 cell
-
 Homo sapiens
-
3.4.21.68 pancreas
-
 Homo sapiens
-
3.4.21.68 SK-PC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
3.4.21.68 plasminogen + H2O pH 7.4, 37°C Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 t-PA
-
 Homo sapiens
3.4.21.68 Tissue-type plasminogen activator
-
 Homo sapiens