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Literature summary extracted from

  • de la Plaza, M.; Fernandez de Palencia, P.; Pelaez, C.; Requena, T.
    Biochemical and molecular characterization of alpha-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids by Lactococcus lactis (2004), FEMS Microbiol. Lett., 238, 367-374.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.1 NaCl up to 3fold increase in activity at pH 5.4 Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.1 1,10-phenanthroline 1 mM, 95% inhibition Lactococcus lactis
4.1.1.1 Cu2+ 1 mM, 95% inhibition Lactococcus lactis
4.1.1.1 ethylendiaminetetraacetate 1 mM, 95% inhibition Lactococcus lactis
4.1.1.1 p-hydroxymercuribenzoate 1 mM, 40% inhibition Lactococcus lactis
4.1.1.1 phosphoramidon 1 mM, 48% inhibition Lactococcus lactis
4.1.1.1 Zn2+ 1 mM, 35% inhibition Lactococcus lactis
4.1.1.72 1,10-phenanthroline 10 mM, 4.5% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 4-hydroxymercuribenzoic acid 1 mM, 59% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 Cu2+ 1 mM, 5.2% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 EDTA 1 mM, 4.3% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 phenylmethanesulfonyl fluoride 1 mM, 71.7% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 phosphoramidon 1 mM, 52% residual activity Lactococcus lactis subsp. lactis
4.1.1.72 Zn2+ 1 mM, 66% residual activity Lactococcus lactis subsp. lactis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.1 1.9
-
2-oxoisovalerate pH 6.5, 37°C Lactococcus lactis
4.1.1.72 1.9
-
2-oxoisovalerate pH 6.5, 37°C Lactococcus lactis subsp. lactis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.1 cytoplasm
-
Lactococcus lactis 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.72 Ca2+ 1 mM, 124% of initial activity Lactococcus lactis subsp. lactis
4.1.1.72 Co2+ 1 mM, 110% of initial activity Lactococcus lactis subsp. lactis
4.1.1.72 Na+ 1 mM, 121% of initial activity Lactococcus lactis subsp. lactis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.1 61000
-
4 * 61000, calculated, 4 * 66000, SDS-PAGE Lactococcus lactis
4.1.1.1 66000
-
4 * 61000, calculated, 4 * 66000, SDS-PAGE Lactococcus lactis
4.1.1.1 240000
-
gel filtration Lactococcus lactis
4.1.1.72 61000
-
4 * 61000, calculated Lactococcus lactis subsp. lactis
4.1.1.72 240000
-
gel filtration Lactococcus lactis subsp. lactis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.1 Lactococcus lactis Q684J7
-
-
4.1.1.72 Lactococcus lactis subsp. lactis Q684J7
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.1 80.7
-
pH 6.5, 37°C Lactococcus lactis
4.1.1.72 80.7
-
pH 6.5, 37°C Lactococcus lactis subsp. lactis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.1 2-oxoisocaproate 22.7% of the activity with 2-oxoisovalerate Lactococcus lactis 3-methylbutanal + CO2
-
?
4.1.1.1 2-oxoisovalerate
-
Lactococcus lactis 2-methylpropanal + CO2
-
?
4.1.1.1 2-oxomethylvalerate 16.7% of the activity with 2-oxoisovalerate Lactococcus lactis ?
-
?
4.1.1.1 3-phenylpyruvate 8.8% of the activity with 2-oxoisovalerate Lactococcus lactis 2-phenylethanal + CO2
-
?
4.1.1.1 4-methylthio-2-oxobutanoate 7.2% of the activity with 2-oxoisovalerate Lactococcus lactis 3-methylthiopropanal + CO2
-
?
4.1.1.1 indole-3-pyruvate 0.1% of the activity with 2-oxoisovalerate Lactococcus lactis 2-(indol-3-yl)-ethanal + CO2
-
?
4.1.1.1 pyruvate 0.6% of the activity with 2-oxoisovalerate Lactococcus lactis ethanal + CO2
-
?
4.1.1.72 2-oxoisocaproate 22.7% of the activity with 2-oxoisovalerate Lactococcus lactis subsp. lactis 3-methylbutanal + CO2
-
?
4.1.1.72 2-oxoisovalerate
-
Lactococcus lactis subsp. lactis 2-methylpropanal + CO2
-
?
4.1.1.72 2-oxomethylvalerate 16.7% of the activity with 2-oxoisovalerate Lactococcus lactis subsp. lactis pentanal + CO2
-
?
4.1.1.72 additional information very poor substrates: indole-3-pyruvate and pyruvate Lactococcus lactis subsp. lactis ?
-
?
4.1.1.72 Phenylpyruvate
-
Lactococcus lactis subsp. lactis Phenylacetaldehyde + CO2 8.8% of the activity with 2-oxoisovalerate ?

Subunits

EC Number Subunits Comment Organism
4.1.1.1 tetramer 4 * 61000, calculated, 4 * 66000, SDS-PAGE Lactococcus lactis
4.1.1.72 tetramer 4 * 61000, calculated Lactococcus lactis subsp. lactis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.1 45
-
-
Lactococcus lactis
4.1.1.72 45
-
-
Lactococcus lactis subsp. lactis

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.1 45
-
30 min, complete inactivation Lactococcus lactis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.1 6.5
-
-
Lactococcus lactis
4.1.1.72 6.5
-
-
Lactococcus lactis subsp. lactis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.1 5.5 7.5
-
Lactococcus lactis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.72 thiamine diphosphate enzyme is a non-oxidative thiamin diphosphate-dependent alpha-oxoacid decarboxylase Lactococcus lactis subsp. lactis