EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.1 | NaCl | up to 3fold increase in activity at pH 5.4 | Lactococcus lactis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.1 | 1,10-phenanthroline | 1 mM, 95% inhibition | Lactococcus lactis | |
4.1.1.1 | Cu2+ | 1 mM, 95% inhibition | Lactococcus lactis | |
4.1.1.1 | ethylendiaminetetraacetate | 1 mM, 95% inhibition | Lactococcus lactis | |
4.1.1.1 | p-hydroxymercuribenzoate | 1 mM, 40% inhibition | Lactococcus lactis | |
4.1.1.1 | phosphoramidon | 1 mM, 48% inhibition | Lactococcus lactis | |
4.1.1.1 | Zn2+ | 1 mM, 35% inhibition | Lactococcus lactis | |
4.1.1.72 | 1,10-phenanthroline | 10 mM, 4.5% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | 4-hydroxymercuribenzoic acid | 1 mM, 59% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | Cu2+ | 1 mM, 5.2% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | EDTA | 1 mM, 4.3% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | phenylmethanesulfonyl fluoride | 1 mM, 71.7% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | phosphoramidon | 1 mM, 52% residual activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | Zn2+ | 1 mM, 66% residual activity | Lactococcus lactis subsp. lactis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.1 | 1.9 | - |
2-oxoisovalerate | pH 6.5, 37°C | Lactococcus lactis | |
4.1.1.72 | 1.9 | - |
2-oxoisovalerate | pH 6.5, 37°C | Lactococcus lactis subsp. lactis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.1.1.1 | cytoplasm | - |
Lactococcus lactis | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.72 | Ca2+ | 1 mM, 124% of initial activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | Co2+ | 1 mM, 110% of initial activity | Lactococcus lactis subsp. lactis | |
4.1.1.72 | Na+ | 1 mM, 121% of initial activity | Lactococcus lactis subsp. lactis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 61000 | - |
4 * 61000, calculated, 4 * 66000, SDS-PAGE | Lactococcus lactis |
4.1.1.1 | 66000 | - |
4 * 61000, calculated, 4 * 66000, SDS-PAGE | Lactococcus lactis |
4.1.1.1 | 240000 | - |
gel filtration | Lactococcus lactis |
4.1.1.72 | 61000 | - |
4 * 61000, calculated | Lactococcus lactis subsp. lactis |
4.1.1.72 | 240000 | - |
gel filtration | Lactococcus lactis subsp. lactis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.1 | Lactococcus lactis | Q684J7 | - |
- |
4.1.1.72 | Lactococcus lactis subsp. lactis | Q684J7 | - |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 80.7 | - |
pH 6.5, 37°C | Lactococcus lactis |
4.1.1.72 | 80.7 | - |
pH 6.5, 37°C | Lactococcus lactis subsp. lactis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.1 | 2-oxoisocaproate | 22.7% of the activity with 2-oxoisovalerate | Lactococcus lactis | 3-methylbutanal + CO2 | - |
? | |
4.1.1.1 | 2-oxoisovalerate | - |
Lactococcus lactis | 2-methylpropanal + CO2 | - |
? | |
4.1.1.1 | 2-oxomethylvalerate | 16.7% of the activity with 2-oxoisovalerate | Lactococcus lactis | ? | - |
? | |
4.1.1.1 | 3-phenylpyruvate | 8.8% of the activity with 2-oxoisovalerate | Lactococcus lactis | 2-phenylethanal + CO2 | - |
? | |
4.1.1.1 | 4-methylthio-2-oxobutanoate | 7.2% of the activity with 2-oxoisovalerate | Lactococcus lactis | 3-methylthiopropanal + CO2 | - |
? | |
4.1.1.1 | indole-3-pyruvate | 0.1% of the activity with 2-oxoisovalerate | Lactococcus lactis | 2-(indol-3-yl)-ethanal + CO2 | - |
? | |
4.1.1.1 | pyruvate | 0.6% of the activity with 2-oxoisovalerate | Lactococcus lactis | ethanal + CO2 | - |
? | |
4.1.1.72 | 2-oxoisocaproate | 22.7% of the activity with 2-oxoisovalerate | Lactococcus lactis subsp. lactis | 3-methylbutanal + CO2 | - |
? | |
4.1.1.72 | 2-oxoisovalerate | - |
Lactococcus lactis subsp. lactis | 2-methylpropanal + CO2 | - |
? | |
4.1.1.72 | 2-oxomethylvalerate | 16.7% of the activity with 2-oxoisovalerate | Lactococcus lactis subsp. lactis | pentanal + CO2 | - |
? | |
4.1.1.72 | additional information | very poor substrates: indole-3-pyruvate and pyruvate | Lactococcus lactis subsp. lactis | ? | - |
? | |
4.1.1.72 | Phenylpyruvate | - |
Lactococcus lactis subsp. lactis | Phenylacetaldehyde + CO2 | 8.8% of the activity with 2-oxoisovalerate | ? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.1.1.1 | tetramer | 4 * 61000, calculated, 4 * 66000, SDS-PAGE | Lactococcus lactis |
4.1.1.72 | tetramer | 4 * 61000, calculated | Lactococcus lactis subsp. lactis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 45 | - |
- |
Lactococcus lactis |
4.1.1.72 | 45 | - |
- |
Lactococcus lactis subsp. lactis |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 45 | - |
30 min, complete inactivation | Lactococcus lactis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 6.5 | - |
- |
Lactococcus lactis |
4.1.1.72 | 6.5 | - |
- |
Lactococcus lactis subsp. lactis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.1 | 5.5 | 7.5 | - |
Lactococcus lactis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.72 | thiamine diphosphate | enzyme is a non-oxidative thiamin diphosphate-dependent alpha-oxoacid decarboxylase | Lactococcus lactis subsp. lactis |