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Literature summary extracted from

  • Pan, F.; Means, A.R.; Liu, J.O.
    Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation (2005), EMBO J., 24, 2104-2113.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin
-
 Homo sapiens
2.7.11.17 ionomycin
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 transient co-expression of CaMKIV, MEF-2, and Cabin1 in murine T-cell hybridoma DO11.10, MEF-2 activation of gene transcription is inhibited by Cabin1, the inhibition is reversed by CaMKIV Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 K75E site-directed mutagenesis, catalytically inactive CaMKIV mutant Homo sapiens
2.7.11.17 additional information introduction of lentivirus shRNA specific for human CaMKIV into human T-cells and Jurkat cells leads to knockdown of CaMKIV expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-62
-
 Homo sapiens
2.7.11.17 W-7 no inhibition by calcineurin inhibitor FK506 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+
-
 Homo sapiens
2.7.11.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + Cabin1 Homo sapiens a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview ADP + phosphorylated Cabin1
-
 ?
2.7.11.17 additional information Homo sapiens Ca2+ signaling in T-cell activation involves transcriptional activity of MEF-2 and NFAT, which is repressed by Cabin1, activated CaMKIV can overcome the repression by Cabin1, crosstalk between Cabin1 and CaMKIV, dissociation of Cabin1 from MEF-2 by the enzyme requires calmodulin, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 T-lymphocyte primary Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + Cabin1 a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, CaMKIV regulates nuclear export of Cabin1 during Ca2+-dependent T-cell activation, regulation overview Homo sapiens ADP + phosphorylated Cabin1
-
 ?
2.7.11.17 ATP + Cabin1 a transcriptional corepressor of myocyte enhancer factor 2, phosphorylation at Ser2126 by CaMKIV creates a docking site for protein 14-3-3, which causes nuclear export, no activity with Cabin1 mutant S2126A Homo sapiens ADP + phosphorylated Cabin1
-
 ?
2.7.11.17 additional information Ca2+ signaling in T-cell activation involves transcriptional activity of MEF-2 and NFAT, which is repressed by Cabin1, activated CaMKIV can overcome the repression by Cabin1, crosstalk between Cabin1 and CaMKIV, dissociation of Cabin1 from MEF-2 by the enzyme requires calmodulin, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calmodulin-dependent protein kinase IV
-
 Homo sapiens
2.7.11.17 CaMKIV
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Homo sapiens