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Literature summary extracted from

  • Brown, S.; Young, H.K.; Amyes, S.G.
    Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina (2005), Clin. Microbiol. Infect., 11, 15-23.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanate 0.1 mM, 50% inhibition Acinetobacter baumannii
3.5.2.6 Cloxacillin 0.398 mM, 50% inhibition Acinetobacter baumannii
3.5.2.6 Imipenem 2.5 mM, 50% inhibition Acinetobacter baumannii
3.5.2.6 meropenem 0.000004 mM, 50% inhibition Acinetobacter baumannii
3.5.2.6 NaCl 3.2 mM, 50% inhibition Acinetobacter baumannii
3.5.2.6 Sulbactam 0.05 mM, 50% inhibition Acinetobacter baumannii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.011
-
 Imipenem 37°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.024
-
 ampicillin 37°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.077
-
 cephaloridine 37°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.129
-
 Cloxacillin 37°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.531
-
 Oxacillin 37°C, pH 7.0 Acinetobacter baumannii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.2.6 35500
-
 x * 35500, SDS-PAGE Acinetobacter baumannii

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Acinetobacter baumannii Q5QT35 from genetically distinct carbapenem-resistant strains from Argentina
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Acinetobacter baumannii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Acinetobacter baumannii (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cloxacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O
-
 Acinetobacter baumannii (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.2.6 ? x * 35500, SDS-PAGE Acinetobacter baumannii

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.5.2.6 Acinetobacter baumannii
-
-
 7