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Literature summary extracted from

  • Lin, G.; Lee, Y.R.; Liu, Y.C.; Wu, Y.G.
    Ortho effects for inhibition mechanisms of butyrylcholinesterase by o-substituted phenyl N-butyl carbamates and comparison with acetylcholinesterase, cholesterol esterase, and lipase (2005), Chem. Res. Toxicol., 18, 1124-1131.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 2-(trifluoromethyl)phenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-chlorophenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-ethylphenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-methoxyphenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-methylphenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-nitrophenyl butylcarbamate
-
 Equus caballus
3.1.1.8 2-tert-butoxyphenyl butylcarbamate
-
 Equus caballus
3.1.1.8 biphenyl-2-yl butylcarbamate
-
 Equus caballus
3.1.1.8 additional information ortho electron domating substitutents of the inhibitors accelerate inhibition of enzyme by ortho polar effects Equus caballus
3.1.1.8 phenyl butylcarbamate
-
 Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Equus caballus
-
 commercial preparation
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 serum
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine + H2O
-
 Equus caballus butanoate + thiocholine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.8 0.0007
-
 2-nitrophenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.04 Equus caballus
3.1.1.8 0.0017
-
 2-(trifluoromethyl)phenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.11 Equus caballus
3.1.1.8 0.0042
-
 2-ethylphenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.4 Equus caballus
3.1.1.8 0.009
-
 phenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.8 Equus caballus
3.1.1.8 0.011
-
 biphenyl-2-yl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.0 Equus caballus
3.1.1.8 0.011
-
 2-methylphenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.1 Equus caballus
3.1.1.8 0.013
-
 2-chlorophenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.6 Equus caballus
3.1.1.8 0.017
-
 2-methoxyphenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 2.5 Equus caballus
3.1.1.8 0.022
-
 2-tert-butoxyphenyl butylcarbamate pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 4 Equus caballus