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Literature summary extracted from

  • Ma, X.; Koepke, J.; Fritzsch, G.; Diem, R.; Kutchan, T.M.; Michel, H.; Stockigt, J.
    Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family (2004), Biochim. Biophys. Acta, 1702, 121-124.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.3.3.2 medicine anti-cancer, anti-hypertensive, anti-malaria and anti-arrhythmic ajmaline agents Rauvolfia serpentina
4.3.3.2 synthesis involved in the biosynthesis of almost all plant monoterpenoid indole alkaloids Rauvolfia serpentina

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.3.2 cloned with His-tag, expression in Escherichia coli strain M15, after expression and Ni-NTA column removed by DAPase Rauvolfia serpentina

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.3.3.2 2.95 A under cryoconditions, crystal growing by hanging drop vapor diffusion, 303 K, 0.8 M potassium sodium tartrate tetrahydrate,pH 7.5 - 8.0 Rauvolfia serpentina

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.3.2 35300
-
 calculated, SDS-PAGE Rauvolfia serpentina

Organism

EC Number Organism UniProt Comment Textmining
4.3.3.2 Rauvolfia serpentina
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.3.2
-
 Rauvolfia serpentina

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.3.2 tryptamine + secologanin
-
 Rauvolfia serpentina 3alpha(S)-strictosidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.3.2 STR1
-
 Rauvolfia serpentina