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Literature summary extracted from

  • Patel, C.N.; Koh, D.W.; Jacobson, M.K.; Oliveira, M.A.
    Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain (2005), Biochem. J., 388, 493-500.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.143 D738N no enzymic activity, no structural effect of mutation Bos taurus
3.2.1.143 E708N 119% of wild-type activity, no structural effect of mutation Bos taurus
3.2.1.143 E728N 18% of wild-type activity, no structural effect of mutation Bos taurus
3.2.1.143 E756N 29% of wild-type activity Bos taurus
3.2.1.143 E756N no enzymic activity, no structural effect of mutation Bos taurus
3.2.1.143 E756N/E757N | no enzymic activity Bos taurus
3.2.1.143 E757N no enzymic activity, no structural effect of mutation Bos taurus
3.2.1.143 E774N 61% of wild-type activity Bos taurus
3.2.1.143 E780N 57% of wild-type activity Bos taurus
3.2.1.143 E788N 100% of wild-type activity Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.143 adenosine diphosphate (hydroxymethyl)-pyrrolidinediol
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Bos taurus O02776 recombinant protein
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 poly(ADP-ribose)n + H2O
-
 Bos taurus ?
-
 ?