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Literature summary extracted from

  • Simm, A.M.; Loveridge, E.J.; Crosby, J.; Avison, M.B.; Walsh, T.R.; Bennett, P.M.
    Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases (2005), Biochem. J., 387, 585-590.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 bulgecin A competitive inhibition of the enzyme in its two-zinc form, but fails to inhibit when the enzyme is in the single-zinc form. The competitive inhibition is restored by restoring the second zinc ion Bacillus cereus
3.5.2.6 bulgecin A partial non-competitive inhibition Stenotrophomonas maltophilia
3.5.2.6 additional information no inhibition by bulgecin A Aeromonas veronii

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Aeromonas veronii
-
 bv. sobria
-
3.5.2.6 Bacillus cereus
-
-
-
3.5.2.6 Stenotrophomonas maltophilia P52700
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 nitrocefin + H2O
-
 Bacillus cereus (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Aeromonas veronii (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Stenotrophomonas maltophilia (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 L1 metallo-beta-lactamase
-
 Stenotrophomonas maltophilia
3.5.2.6 metallo-beta-lactamase BceII
-
 Bacillus cereus
3.5.2.6 metallo-beta-lactamase ImiS
-
 Aeromonas veronii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.2.6 0.0025
-
 bulgecin A 25°C, pH 7.0 Stenotrophomonas maltophilia
3.5.2.6 0.23
-
 bulgecin A 25°C, pH 7.0 Bacillus cereus