Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Plummer, G.; Perreault, K.R.; Holmes, C.F.; Posse De Chaves, E.I.
    Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons (2005), Biochem. J., 385, 685-693.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 C6-ceramide activates in vivo and 2-3fold in vitro, blocked by protein phosphatase inhibitor-2, i.e. I-2, ceramide prevents retinoblastoma gene product pRb hyperphosphorylation by PP1 activation Rattus norvegicus
3.1.3.16 additional information nerve growth factor is required for PP activation in vivo Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 additional information no inhibition by okadaic acid Rattus norvegicus
3.1.3.16 protein phosphatase inhibitor-2 i.e. I-2, specific for PP1 Rattus norvegicus
3.1.3.16 tautomycin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 additional information Rattus norvegicus ceramide-induced cell survival mechanism, overview ?
-
 ?
3.1.3.16 phosphorylated pRb protein + H2O Rattus norvegicus ceramide prevents retinoblastoma gene product pRb protein hyperphosphorylation by PP1 activation, nerve growth factor deprivation in sympathetic neurons leads to inhibition of PP1 and hyperphosphorylation of pRb protein pRb protein + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 neuron untreated and nerve growth factor-deprived sympathetic neurons Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 additional information ceramide-induced cell survival mechanism, overview Rattus norvegicus ?
-
 ?
3.1.3.16 phosphorylated pRb protein + H2O
-
 Rattus norvegicus pRb protein + phosphate
-
 ?
3.1.3.16 phosphorylated pRb protein + H2O ceramide prevents retinoblastoma gene product pRb protein hyperphosphorylation by PP1 activation, nerve growth factor deprivation in sympathetic neurons leads to inhibition of PP1 and hyperphosphorylation of pRb protein Rattus norvegicus pRb protein + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 PP-1
-
 Rattus norvegicus
3.1.3.16 serine/threonine protein phosphatase-1
-
 Rattus norvegicus