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Literature summary extracted from

  • Heritier, C.; Poirel, L.; Fournier, P.E.; Claverie, J.M.; Raoult, D.; Nordmann, P.
    Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii (2005), Antimicrob. Agents Chemother., 49, 4174-4179.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.2.6
-
 Acinetobacter baumannii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.13
-
 nitrocefin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.19
-
 cephalothin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.24
-
 ampicillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.71
-
 benzylpenicillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 2.5
-
 cephaloridine 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 2.8
-
 ticarcillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 3.6
-
 Imipenem 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 3.7
-
 Oxacillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 4
-
 piperacillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 4.5
-
 meropenem 30°C, pH 7.0 Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.2.6 additional information Acinetobacter baumannii no induction by imipenem and cefoxitin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Acinetobacter baumannii Q5I2N2 clinical isolate
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Acinetobacter baumannii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Acinetobacter baumannii (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O
-
 Acinetobacter baumannii (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O
-
 Acinetobacter baumannii (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 meropenem + H2O
-
 Acinetobacter baumannii (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 additional information no induction by imipenem and cefoxitin Acinetobacter baumannii ?
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Acinetobacter baumannii (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 piperacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 OXA-69
-
 Acinetobacter baumannii
3.5.2.6 oxycillinase
-
 Acinetobacter baumannii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 0.004
-
 cephalothin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.05
-
 cephaloridine 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.06
-
 ampicillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.06
-
 meropenem 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.1
-
 Imipenem 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.2
-
 benzylpenicillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.2
-
 piperacillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.2
-
 Oxacillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.3
-
 ticarcillin 30°C, pH 7.0 Acinetobacter baumannii
3.5.2.6 0.4
-
 nitrocefin 30°C, pH 7.0 Acinetobacter baumannii