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Literature summary extracted from

  • Lodowski, D.T.; Pitcher, J.A.; Capel, W.D.; Lefkowitz, R.J.; Tesmer, J.J.
    Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma (2003), Science, 300, 1256-1262.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 G protein GRK2 binds G protein beta1gamma2 subunits, binding structure, overview Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 co-overexpression of GRK2 and G protein beta1gamma2 subunits in Spodoptera frugiperda Sf9 cells using the baculovirus infection system Bos taurus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.15 purified recombinant GRK2 in complex with purified recombinant G protein beta1gamma2 subunits, X-ray diffraction structure determination and analysis at 2.5 A resolution, modeling Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 membrane associated, GRK2 in complex with G protein beta1gamma2 subunits Bos taurus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 additional information Bos taurus phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.15 ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] substrate and activator binding site structure, active site structure, structure-function relationship, overview Bos taurus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 additional information phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways Bos taurus ?
-
 ?
2.7.11.15 additional information the enzyme contains regulatory sites for Ca2+/calmodulin, protein kinase C, and clathrin Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.15 More GRK2 consists of 3 modular domains: a predominantly N-terminal RGS homology domain, a central protein kinase domain, and a C-terminal pleckstrin homology domain, domain functions, overview Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 G protein-coupled receptor kinase 2
-
 Bos taurus
2.7.11.15 GRK2
-
 Bos taurus
2.7.11.15 guanine nucleotide-binding protein-coupled receptor kinase
-
 Bos taurus