Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tsukada, Y.; Fang, J.; Erdjument-Bromage, H.; Warren, M.E.; Borchers, C.H.; Tempst, P.; Zhang, Y.
    Histone demethylation by a family of JmjC domain-containing proteins (2006), Nature, 439, 811-816.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.27 ascorbate required for optimal activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.27 H212A mutation completely abolishes the enzymatic activity Homo sapiens
1.14.11.27 H305A mutation completely abolishes the enzymatic activity Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.27 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.27 Fe2+ required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.27 Homo sapiens
-
-
-
1.14.11.27 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.27 recombinant enzyme purified from baculovirus-infected Sf9 cells Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.27 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.27 protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Saccharomyces cerevisiae protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
1.14.11.27 protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Saccharomyces cerevisiae protein L-lysine + succinate + formaldehyde + CO2
-
 ?
1.14.11.27 protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Homo sapiens protein N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
1.14.11.27 protein N6-methyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Homo sapiens protein L-lysine + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.27 H3-K36 demethylase
-
 Homo sapiens
1.14.11.27 H3-K36 demethylase
-
 Saccharomyces cerevisiae
1.14.11.27 H3-K36-specific demethylase
-
 Homo sapiens
1.14.11.27 histone-lysine(H3-K36) demethylase
-
 Homo sapiens
1.14.11.27 JHDM1A
-
 Homo sapiens
1.14.11.27 JmjC domain-containing histone demethylase 1
-
 Homo sapiens
1.14.11.27 JmjC domain-containing histone demethylase 1A
-
 Homo sapiens
1.14.11.27 scJHDM1
-
 Saccharomyces cerevisiae