Literature summary extracted from

Gong, C.; Bongiorno, P.; Martins, A.; Stephanou, N.C.; Zhu, H.; Shuman, S.; Glickman, M.S.
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C (2005), Nat. Struct. Mol. Biol., 12, 304-312.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.5.1.1	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	Mycolicibacterium smegmatis	template-dependent and template-independent polymerase functions. LigD directs an imprecise non-homologous end-joining pathway for repairing blunt double-strand breaks. Another ATP-dependent DNA ligase (LigC) provides backup mechanism for LigD-independent error-prone repair of blunt-end double-strand breaks	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.5.1.1	Mycolicibacterium smegmatis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.5.1.1	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	template-dependent and template-independent polymerase functions. LigD directs an imprecise non-homologous end-joining pathway for repairing blunt double-strand breaks. Another ATP-dependent DNA ligase (LigC) provides backup mechanism for LigD-independent error-prone repair of blunt-end double-strand breaks	Mycolicibacterium smegmatis	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?
6.5.1.1	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	template-dependent and template-independent polymerase functions	Mycolicibacterium smegmatis	AMP + diphosphate + (deoxyribonucleotide)m+n	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
6.5.1.1	ATP-dependent DNA ligase	-	Mycolicibacterium smegmatis
6.5.1.1	LigC	-	Mycolicibacterium smegmatis
6.5.1.1	LigD	-	Mycolicibacterium smegmatis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)