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Literature summary extracted from

  • Chen, L.W.; Egan, L.; Li, Z.W.; Greten, F.R.; Kagnoff, M.F.; Karin, M.
    The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion (2003), Nat. Med., 9, 575-581.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.10 additional information type 1 TNFalpha induces the enzyme activity Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.10 additional information disruption of the gene encoding IKKbeta leads to apoptotic tissue damage, e.g. in mucosa, and prevention of systemic inflammatory response, which results in the multiple organ dysfunction syndrome MODS Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 additional information Mus musculus activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection ?
-
 ?
2.7.11.10 additional information Mus musculus C57/BL6J activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Mus musculus
-
 C57BI/6J mice
-
2.7.11.10 Mus musculus C57/BL6J
-
 C57BI/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 enterocyte
-
 Mus musculus
-
2.7.11.10 intestinal mucosa
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus ?
-
 ?
2.7.11.10 additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
-
 Mus musculus