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Literature summary extracted from

  • Morris, A.J.; Rudge, S.A.; Mahlum, C.E.; Jenco.John, M.
    Regulation of phosphoinositide-3-kinase by G protein bg subunits in a rat osteosarcoma cell line (1995), Mol. Pharmacol., 48, 532-539.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.153 G-protein beta,gamma subunit purified from bovine brain, 16fold activitation at 0.016 mM Rattus norvegicus
2.7.1.153 guanosine 5'-3-O-(thio)triphosphate up to 3fold increase in activity, activation is blocked by high concentrations of guanosine-5’-2-O-(thio)diphosphate Rattus norvegicus
2.7.1.153 thrombin activation of enzyme in intact cells, blocked by pertussis toxin Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.153 cytosol
-
 Rattus norvegicus 5829
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Rattus norvegicus Q9Z1L0 beta-isoform
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 ROS-17/2.8 cell rat osteosarcoma cell line Rattus norvegicus
-