Literature summary extracted from

McCoy, A.J.; Maurelli, A.T.
Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivity (2005), Mol. Microbiol., 57, 41-52.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
6.3.2.4	expressed in Escherichia coli ATM697 and ATM718 as a fusion protein MurC-Ddl	Chlamydia trachomatis

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.2.4	D-cycloserine	-	Chlamydia trachomatis

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
6.3.2.4	0.017	-	ATP	-	Chlamydia trachomatis

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.3.2.4	ATP + D-alanine	Chlamydia trachomatis	-	ADP + phosphate + D-alanyl-D-alanine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.4	Chlamydia trachomatis	-	serovar L2	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
6.3.2.4	-	Chlamydia trachomatis

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.4	ATP + D-alanine	-	Chlamydia trachomatis	ADP + phosphate + D-alanyl-D-alanine	-	?
6.3.2.4	D-cycloserine	-	Chlamydia trachomatis	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
6.3.2.4	Ddl	-	Chlamydia trachomatis

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
6.3.2.4	48.5	-	D-alanine	-	Chlamydia trachomatis

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
6.3.2.4	0.002	-	D-cycloserine	-	Chlamydia trachomatis

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Release 2023.1 (January 2023)