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Literature summary extracted from

  • Pederson, K.J.; Pal, S.; Vallis, A.J.; Frank, D.W.; Barbieri, J.T.
    Intracellular localization and processing of Pseudomonas aeruginosa ExoS in eukaryotic cells (2000), Mol. Microbiol., 37, 287-299.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 perinuclear space localizes in eukaryotic cells to the perinuclear region Pseudomonas aeruginosa
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Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Pseudomonas aeruginosa
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.2.30 proteolytic modification the full-length form is processed to a soluble fragment, which possesses both the GAP and ADP-ribosyltransferase activities Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor ExoS is a type III cytotoxin which modulates two eukaryotic signalling pathways. The N-terminus (residues 1-234) is a GTPase activating protein for RhoGTPases, while the C-terminus (residues 232-453) encodes an ADP-ribosyltransferase Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 ExoS
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 Pseudomonas aeruginosa