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Literature summary extracted from

  • Spiridonov, N.A.; Wong, L.; Zerfas, P.M.; Starost, M.F.; Pack, S.D.; Paweletz, C.P.; Johnson, G.R.
    Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility (2005), Mol. Cell. Biol., 25, 4250-4261.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of Myc-tagged SSTK in 293T cells Mus musculus
2.7.11.1 SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of wild-type and mutant Myc-tagged SSTK in 293T cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 K41M site-directed mutagenesis, inactive mutant, no interaction with heat shock proteins Homo sapiens
2.7.11.1 additional information construction of SSTK knockout mice showing impaired sperm motility and morphology resulting in male sterility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 additional information Homo sapiens serine/threonine protein kinase is SSTK essential for male fertility ?
-
 ?
2.7.11.1 additional information Mus musculus serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens Q9BXA6
-
-
2.7.11.1 Mus musculus Q925K9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 additional information SSTK is ubiquitously expressed in human tissue Homo sapiens
-
2.7.11.1 spermatid head of spermatid Mus musculus
-
2.7.11.1 testis
-
 Mus musculus
-
2.7.11.1 testis most abundant in Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + histone H1 substrate from calf, substrate of SSTK Homo sapiens ADP + phosphorylated histone H1
-
 ?
2.7.11.1 ATP + histone H1 substrate from calf, substrate of SSTK Mus musculus ADP + phosphorylated histone H1
-
 ?
2.7.11.1 ATP + histone H2A recombinant human substrate, substrate of SSTK Homo sapiens ADP + phosphorylated histone H2A
-
 ?
2.7.11.1 ATP + histone H2A recombinant human substrate, substrate of SSTK Mus musculus ADP + phosphorylated histone H2A
-
 ?
2.7.11.1 ATP + histone H2AX recombinant human substrate, substrate of SSTK Homo sapiens ADP + phosphorylated histone H2AX
-
 ?
2.7.11.1 ATP + histone H2AX recombinant human substrate, substrate of SSTK Mus musculus ADP + phosphorylated histone H2AX
-
 ?
2.7.11.1 ATP + histone H2B recombinant human substrate, substrate of SSTK Homo sapiens ADP + phosphorylated histone H2B
-
 ?
2.7.11.1 ATP + histone H2B recombinant human substrate, substrate of SSTK Mus musculus ADP + phosphorylated histone H2B
-
 ?
2.7.11.1 ATP + histone H4 recombinant substrate from Xenopus laevis, substrate of SSTK Homo sapiens ADP + phosphorylated histone H4
-
 ?
2.7.11.1 ATP + histone H4 recombinant substrate from Xenopus laevis, substrate of SSTK Mus musculus ADP + phosphorylated histone H4
-
 ?
2.7.11.1 ATP + myelin basic protein
-
 Homo sapiens ADP + phosphorylated myelin basic protein
-
 ?
2.7.11.1 ATP + myelin basic protein
-
 Mus musculus ADP + phosphorylated myelin basic protein
-
 ?
2.7.11.1 additional information serine/threonine protein kinase is SSTK essential for male fertility Homo sapiens ?
-
 ?
2.7.11.1 additional information serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins Mus musculus ?
-
 ?
2.7.11.1 additional information substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signal proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity Mus musculus ?
-
 ?
2.7.11.1 additional information substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.1 More SSTK is a small enzyme consisting only of the C- and N-terminal lobe of a protein kinase catalytic domain Homo sapiens
2.7.11.1 More SSTK is a small enzyme consisting only of the C- and N-terminal lobe of a protein kinase catalytic domain Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 serine/threonine protein kinase
-
 Homo sapiens
2.7.11.1 serine/threonine protein kinase
-
 Mus musculus
2.7.11.1 SSTK
-
 Homo sapiens
2.7.11.1 SSTK
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Homo sapiens
2.7.11.1 ATP
-
 Mus musculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.11.1 Homo sapiens amino acid sequence calculation
-
 9.1
2.7.11.1 Mus musculus amino acid sequence calculation
-
 9.1