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Literature summary extracted from

  • Murakami, T.; Matsuo, M.; Shimizu, A.; Shimomura, Y.
    Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors (2005), J. Nutr. Sci. Vitaminol., 51, 48-50.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 alpha-Chloroisocaproate activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex Rattus norvegicus
1.2.4.4 alpha-Ketoisocaproate activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex Rattus norvegicus
1.2.4.4 alpha-ketoisovalerate activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex Rattus norvegicus
1.2.4.4 additional information clofibric acid and thiamine diphosphate have no effect on the protein-protein interaction between branched-chain alpha-keto acid dehydrogenase kinase and BCKD complex Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 alpha-Chloroisocaproate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
2.7.11.4 alpha-Ketoisocaproate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
2.7.11.4 alpha-ketoisovalerate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
2.7.11.4 additional information clofibric acid and thiamine diphosphate do not affect the protein-protein interaction of BDK with the BCKD complex Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase Rattus norvegicus the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Rattus norvegicus
-
-
-
2.7.11.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 liver
-
 Rattus norvegicus
-
2.7.11.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism Rattus norvegicus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase phosphorylation of the branched-chain alpha-keto acid dehydrogenase complex leads to its inactivation, BDK itself is regulated via protein-protein interaction with the BCKD complex Rattus norvegicus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.4 BCKDC
-
 Rattus norvegicus
1.2.4.4 branched-chain alpha-keto acid dehydrogenase complex
-
 Rattus norvegicus
2.7.11.4 BDK
-
 Rattus norvegicus
2.7.11.4 branched-chain alpha-keto acid dehydrogenase kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.4 ATP
-
 Rattus norvegicus