EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | additional information | ERK phosphorylation activates the enzyme activity, stimulation by 7TMD receptors, e.g. the serotonin 5-HT2c receptor | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.24 | expression of ERK in CHO cells, co-expression of serotonin 5-HT2c receptor leads to increased ERK phosphorylation | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | tyrphostin AG1478 | EGFR-specific antagonist | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.24 | ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.24 | additional information | Homo sapiens | signaling pathway, including ERK, regulation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.1 | Homo sapiens | - |
- |
- |
2.7.11.24 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.24 | phosphoprotein | ERKs are phosphorylated, involving protein kinase C and phospholipase D, in signaling pathways by kinases, which are stimulated by the serotonin 5-HT2c receptor, ERK phosphorylation activates its enzyme activity, overview | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.24 | brain | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | additional information | serotonin 5-HT2c receptor signaling is largely independent from receptor tyrosine kinase activity | Homo sapiens | ? | - |
? | |
2.7.11.24 | ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
2.7.11.24 | additional information | signaling pathway, including ERK, regulation, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.1 | Egfr | - |
Homo sapiens |
2.7.10.1 | EGFR tyrosine kinase | - |
Homo sapiens |
2.7.10.1 | receptor tyrosine kinase | - |
Homo sapiens |
2.7.11.24 | ERK1 | - |
Homo sapiens |
2.7.11.24 | ERK2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | ATP | - |
Homo sapiens |