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Literature summary extracted from
- AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2) (2003), J. Ind. Microbiol. Biotechnol., 30, 462-467.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.1 | KbpA | an AfsK-binding protein activates and modulates the enzyme activity | Streptomyces coelicolor |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.7.11.1 | expression of AsfK and AsfR in Escherichia coli, expression of PkaG and SCD10.09 in Escherichia coli | Streptomyces coelicolor |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.1 | K-252a | - |
Streptomyces coelicolor |  |
| 2.7.11.1 | staurosporine | - |
Streptomyces coelicolor | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.1 | Mg2+ | - |
Streptomyces coelicolor | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.1 | ATP + AfsR protein | Streptomyces coelicolor | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | ATP + AfsR protein | Streptomyces coelicolor A3(2) | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | additional information | Streptomyces coelicolor | AfsK is a Hanks-type protein kinase | ? | - |
? | |
| 2.7.11.1 | additional information | Streptomyces coelicolor A3(2) | AfsK is a Hanks-type protein kinase | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.11.1 | Streptomyces coelicolor | - |
gene afsK | - |
| 2.7.11.1 | Streptomyces coelicolor A3(2) | - |
gene afsK | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 2.7.11.1 | phosphoprotein | AfsK is autophosphorylated at serine and threonine residues leading to its activation, PkaG and SCD10.09 are autophosphorylated at serine and threonine residues | Streptomyces coelicolor |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.1 | ATP + AfsR protein | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | Streptomyces coelicolor | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | ATP + AfsR protein | phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR | Streptomyces coelicolor | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | ATP + AfsR protein | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | Streptomyces coelicolor A3(2) | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | ATP + AfsR protein | phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR | Streptomyces coelicolor A3(2) | ADP + AfsR phosphoprotein | - |
? | |
| 2.7.11.1 | additional information | AfsK is a Hanks-type protein kinase | Streptomyces coelicolor | ? | - |
? | |
| 2.7.11.1 | additional information | AfsK, PkaG, and SCD10 perform autophosphorylation | Streptomyces coelicolor | ? | - |
? | |
| 2.7.11.1 | additional information | AfsK is a Hanks-type protein kinase | Streptomyces coelicolor A3(2) | ? | - |
? | |
| 2.7.11.1 | additional information | AfsK, PkaG, and SCD10 perform autophosphorylation | Streptomyces coelicolor A3(2) | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.11.1 | AsfK | - |
Streptomyces coelicolor |
| 2.7.11.1 | PkaG | - |
Streptomyces coelicolor |
| 2.7.11.1 | SCD10.09 | - |
Streptomyces coelicolor |
| 2.7.11.1 | serine/threonine kinase | - |
Streptomyces coelicolor |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.1 | ATP | - |
Streptomyces coelicolor | |
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