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Literature summary extracted from

  • Kim, H.Y.; Park, E.J.; Joe, E.H.; Jou, I.
    Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia (2003), J. Immunol., 171, 6072-6079.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 curcumin inhibits the JAK-STAT signaling cascade via activation of SHP-2, a SH2 domain-containing phosphatase, and increase in JAK-SHP-2 interaction contributing to anti-inflammatory activity in the brain, suppresses STAT-responsive inflammatory gene expression Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 additional information Homo sapiens the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
 JAK1 and JAK2
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein phosphorylation of JAK1 and JAK2, can be inhibited by curcumin Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 additional information the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Homo sapiens