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Literature summary extracted from

  • Ebmeier, C.C.; Anderson, R.J.
    Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens (2004), J. Clin. Endocrinol. Metab., 89, 5597-5605.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 2,6-Dichloro-4-nitrophenol IC50: 0.0019 mM, enzyme form SULT1A1; IC50: 0.52 mM, enzyme form SULT1A3 Homo sapiens
2.8.2.1 daidzein 0.01 mM, 29% inhibition, enzyme form SULT1A3; 0.01 mM, 69% inhibition, enzyme form SULT1A1 Homo sapiens
2.8.2.1 genistein 0.01 mM, 19% inhibition, enzyme form SULT1A3; 0.01 mM, 80% inhibition, enzyme form SULT1A1 Homo sapiens
2.8.2.1 NaCl IC50: 178.7 mM, enzyme form SULT1A3; IC50: 62.5 mM, enzyme form SULT1A1 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.17
-
 3'-phosphoadenylylsulfate enzyme form SULT1A3 Homo sapiens
2.8.2.1 0.51
-
 3'-phosphoadenylylsulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.58
-
 4-nitrophenol enzyme form SULT1A1 Homo sapiens
2.8.2.1 11.3
-
 dopamine enzyme form SULT1A3 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 enzyme form SULT1A1
-
2.8.2.1 Homo sapiens
-
 enzyme form SULT1A3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 thyroid gland activity in autoimmune thyroid disease glands is significantly higher than in normal thyroids, enzyme form SULT1A3 Homo sapiens
-
2.8.2.1 thyroid gland activity in autoimmune thyroid disease glands is significantly higher than in normal thyroids, SULT1A1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 phenol sulfotransferase 1A1
-
 Homo sapiens
2.8.2.1 phenol sulfotransferase 1A3
-
 Homo sapiens
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.1 SULT1A3
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.8.2.1 39
-
 15 min, 50% of the activity remains, enzyme form SULT1A3 Homo sapiens
2.8.2.1 44
-
 15 min, 50% of the activity remains, enzyme form SULT1A1 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8.2.1 0.0019
-
 IC50: 0.0019 mM, enzyme form SULT1A1 Homo sapiens 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.52
-
 IC50: 0.52 mM, enzyme form SULT1A3 Homo sapiens 2,6-Dichloro-4-nitrophenol
2.8.2.1 62.5
-
 IC50: 62.5 mM, enzyme form SULT1A1 Homo sapiens NaCl
2.8.2.1 178.7
-
 IC50: 178.7 mM, enzyme form SULT1A3 Homo sapiens NaCl